glutathione midpoint potential Measurement of the Redox Potentials in Membraneless Organelles Redox midpoint potentials of glutathionylated

Selective expression of the three classes of glutathione S-transferase isoenzymes in mouse tissues

[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Cuperlovic-Culf M., Cormier K., Touaibia M., Reyjal J., Robichaud S., Belbraouet M., Turcotte S

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ATPDependent Glutathione Disulphide Transport Mediated by the MRP GeneEncoded Conjugate Export Pump. Biochemical Journal 314: 433437

432 High p53 activity reduces the transcription of SLC7A11 and the antioxidant potential of frataxin-deficient cells, therefore, inhibiting P53 activity to improve system Xc and GSH content may be a potential therapeutic strategy to combat oxidative stress and possible ferroptosis in Friedreichs Ataxia

In these contexts, Hedgehog functions as a driver pathway, whereas in other tumor types, it may play a more supportive, context-dependent role