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Author contributions WW, CY, and HD wrote and edited the manuscript

Contraindications/Precautions Cyanocobalamin is contraindicated in those with hypersensitivity to cobalt moiety or cobalamin molecule due to the risk of anaphylaxis (9)

It is thought to interact with beta-3 adrenergic receptors, which are involved in regulating fat metabolism

While hGH did produce a slight increase in glycerol in the knockout mice, the response was markedly lower than in WT animals

Limitations to Consider: The absorption variability creates uncertainty about whether youre receiving therapeutic doses

Bone turnover markers: OVX control group: OC decreased by 40% and CTX increased by 80%