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J Biochem 136(3):261265

[Google Scholar] 4.Lord C, Risi S, Lambrecht L, Cook EH Jr, Leventhal BL, DiLavore PC, et al
In patients with SAH, a study showed that the 90-day survival rate of patients receiving healthy donor FMT treatment was as high as 87.5%, significantly better than patients receiving only corticosteroid treatment (64.3%) or high-dose probiotic infusion (55%), and FMT significantly improved gut flora dysbiosis, increased beneficial flora, and reduced pathogenic bacteria

Additionally, macrophages exhibit synergistic characteristics of dynamic phenotypic conversion and functional remodeling in response to DAMPs: during the acute injury phase, DAMPs (such as high-mobility group box protein B1 and adenosine triphosphate) activate the Toll-like receptor 4/P2X7 receptor pathway, which in turn activates the NF-B and NLRP3 inflammasome, driving macrophages toward M1 polarization and the secretion of pro-inflammatory factors such as interleukin-1(IL-1) and tumor necrosis factor- (TNF-), thereby establishing an efficient pathogen clearance mechanism (Gong et al., 2020) (193)

Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice

P., Riggs D
