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doi: 10.3389/fphar.2026.1759697 Received 03 December 2025 Revised 19 January 2026 Accepted 22 January 2026 Published 06 March 2026 Volume 17 - 2026 Edited by Micha Tomczyk, Medical University of Bialystok, Poland Reviewed by Ramoji Kosuru, Versiti Blood Research Institute, United States vila-Villarreal Gabriela, Autonomous University of Nayarit, Mexico Updates Copyright 2026 Liu, Yu, Nurlan, Wu and Zhao

In contrast, under sustained, excessive, or complex inflammatory conditions, often accompanied by additional stressors such as metabolic burden or systemic infection, OCTN1 expression and function are substantially suppressed, likely reflecting cellular dysfunction, reprogrammed transcriptional networks, or cytokine-mediated inhibitory signaling

Heres what the research shows: Metformin works by reducing glucose production in the liver and improving the bodys use of existing insulin

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