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NRF2 is the master switch of the cellular antioxidant response: when oxidative stress is sensed, KEAP1 (the NRF2 repressor) is oxidized at critical cysteine residues, releasing NRF2 for nuclear translocation and ARE-driven upregulation of the complete antioxidant gene set including GCLC, GCLM, GSR, GPX1, GSTP1, and the thioredoxin system

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