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As proof, ASCT2 ( SLC1A5 ) knockdown in osteosarcoma and cervical cancer cells can induce upregulation of SNAT1 ( SLC38A1 ) (Broer et al., Glutamine catabolism, namely glutaminolysis, begins with its conversion to glutamate, which is catalyzed by the glutaminase (GLS) (Hassanein et al., Figure 1)

These effects are mostly due to compounds that cause induction or inhibition of the enzymes responsible for oxidative metabolism belonging to the cytochrome P450 (CYP) family, the main system used to eliminate drugs from the body [48]-[50]

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Article CAS PubMed PubMed Central Google Scholar Chen PF, Tsai AL, Wu KK

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