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Nat Rev Rheumatol 19 , 96110 (2023)
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This will activate the bodys innate immunity with the release of cytokines such as interleukin 1, alpha (IL-1) in the keratinocytes
The early deficiency in enzyme activity may result from insufficient enzyme synthesis, inhibition of enzymatic activity by naturally occurring substances, deficient synthesis of the glucuronide donor UDPGA, or a combination of these factors
Loe et al, 1998)
