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Description
Because of tissue damage, ALT and AST increased, and, typically, ALT will be raised to a greater extent than AST [25]

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Other possible mechanisms to improve insulin sensitivity in NAFLD reported in the literature include the regulation of the acetyl-CoA/CoA ratio in mitochondria, modulation of the pyruvate dehydrogenase complex (PDHC) activity, altering the expression of glycolytic and gluconeogenic enzymes as well as the expression of genes associated with the insulin signaling cascade, and stimulation of the insulin-like growth factor-1 (IGF-1) axis and IGF-1 signaling cascade (34, 55)

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Transamination refers to a metabolic process where an amino acid is taken from one amino acid group and transferred to a keto acid