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It results from atherosclerosis in the peripheral arteries of the legs, which causes an insufficient arterial blood supply during exercise, resulting in anaerobic metabolism in the muscles with the production of lactic acid and other metabolites

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Kim HB, Kim YJ, Lee YJ, Yoo JY, Choi Y, Kim EM, et al

Free Radic Biol Med 106:368378 Buchert R, Tawamie H, Smith C et al (2014) A peroxisomal disorder of severe intellectual disability, epilepsy, and cataracts due to fatty acyl-CoA reductase 1 deficiency

Because the laser has already broken down the fat cells, this removal process is smoother and less traumatic to surrounding tissues than traditional liposuction