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doi: 10.1530/EJE-22-0647 224 AkirovALaroucheVAlshehriSAsaSLEzzatS

4.4.4 Targeting the Nrf2GPX4 signaling pathway to inhibit ferroptosis in PD Nuclear factor erythroid 2-related factor 2 (Nrf2) functions as a master regulator of cellular antioxidant defenses and plays a direct role in modulating GSH biosynthesis, enhancing oxidative stress resistance, and suppressing ferroptosis (275, 276)

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To enhance therapeutic precision and minimize unintended effects, future studies should explore targeted delivery methods or utilize cell-specific genetic tools to dissect irisins mechanisms of action more accurately
