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(2023, October 2)

The most frequent symptoms are: Developmental delays Anaemia Loss of appetite Chronic vomiting Weight loss Low brain volume Spasms/cramps Apathy Irritability In the most severe instance, vitamin B12 deficiency can lead to respiratory failures and coma (51)

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32,33 A minority of patients exhibit mental or psychiatric disturbances (psychosis) or autonomic signs (bladder, erectile dysfunction, and orthostatic hypotension)

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Combined with biomarker testing and provider assessment, genetic insights can support more personalized metabolic conversations