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Without sufficient magnesium, the enzyme ATPase cannot efficiently break down ATP to release its stored energy, leaving cells functionally starved even if nutrient intake is adequate

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Notably, organs with high iron requirements and energy demands, such as the cardiovascular and nervous systems, are particularly affected [69, 70]

In contrast, Downregulation of HO1 and Nrf2 causes -synuclein aggregation (He et al