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Simple replacement of the AdoCbl with the smaller upper ligand found in methylcobalamin, hydroxycobalamin or cyanocobalamin does not increase DGC activity (Fig
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doi:10.3945/ajcn.111.013458 Ermens AA, Vlasveld LT, Lindemans J

SH groups activate many enzyme systems involved in protein synthesis as well as fat and carbohydrate metabolism
