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Therapeutic Targeting of NNMT 6.1 Inhibitor Development Multiple NNMT inhibitorsincluding natural compounds like yuanhuadinehave shown promise in sensitizing cancer cells to existing therapies and reducing proliferation
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The NGLY1NFE2L1 axis indirectly promotes the stability of GPX4 protein, helping to suppress ferroptosis in certain cells, potentially by modulating the expression or function of proteasome genes [177]
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