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Clinical trials have shown injections of botulinum toxin into the muscular bladder wall can effectively inhibit muscle and nerve hypersensitivity, reduce inflammation, and relieve some symptoms of IC/BPS

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Acknowledgements We thank Professor Hongmei Li from Department of Neuroscience, Mayo Clinic and Yingjun Zhao from Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University for their critical review of this manuscript

The FDA maintains lists of substances that can and cannot be used by compounding pharmacies under sections 503A and 503B of the Federal Food, Drug, and Cosmetic Act

[Google Scholar] 36.Grgic T, Grgic D, Drmic D, Sever AZ, Petrovic I, Sucic M, Kokot A, Klicek R, Sever M, Seiwerth S, et al