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Preclinical research has shown that chemotherapeutic agents such as oxaliplatin, paclitaxel, cyclophosphamide, methotrexate, 5-fluorouracil or doxorubicin can induce short- and long-term deleterious effects in working memory and fear and spatial learning in a wide variety of rodent models (Table 1)

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doi: 10.1111/cns.13207 Pubmed Abstract CrossRef Google Scholar View reference in article 7 SmithTJJohnsonCRKoshyRHessSYQureshiUAMynakMLet al

2.Individual Baseline Neurological Status For individuals suffering from significant synaptic loss-whether due to aging, injury, or disease-the potential for neural repair is greater

Analyst 123 , 28292834 (1998)

The METAOD005 12-week murine study used 300 models across five concentration groups plus one control group and reported a statistically significant mean mass reduction in one peptide-exposed group with improved lipid markers, again limited to obese models