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These observations coupled with the findings of the intervention studies [46, 47] suggest that future studies should examine multiple nutritional status biomarkers of pathways linked with the -glutamyl cycle (e.g

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Consequently, diminished autophagy and mitophagy programs weaken astrocytic neurotrophic and synaptogenic support, causing APOE4 astrocytes to fail in supporting neuronal survival [33,144,157]

The ratio between these two forms determines a cell's redox state and, by extension, its functional health

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What is more alarming than presenting with cognitive impairment is the potential of setting off a bleak trajectory of underlying accelerated brain aging and neurodegenerative disorders, which necessitates being equipped with knowledge of both the molecular underpinnings and the potential solutions