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Alzheimers Disease Preclinical: Progressive decline of endogenous PACAP levels correlates with the pathological severity of cognitive decline in post-mortem analysis of human MCI and AD patient brains [199]

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The best outcome is the one where the PCAC evaluates each compound on its own meritspreclinical evidence, human data, manufacturing feasibility, clinical needand makes recommendations that reflect the actual state of the science, not the political winds

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