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For example, the accumulated lactic acid induced by hypoxia could reduce antigen presentation and inhibit NK cell activity by inhibiting DC differentiation, which would further promote the infiltration of M2-TAMs (tumor-associated macrophages) and other immunosuppressive cells into the solid tumors (7)

Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing

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Hong T, Zhao T, He W, Xia J, Huang Q, Yang J, Gu W, Chen C, Zhang N, Liu Y, et al

hence they interfere with normal hormone receptors, altering the hormonal action of the endocrine glands