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High concentrations of fumarate bind to glutathione, augmenting ROS signaling and accumulation, as observed in not only in vitro models but also in vivo models 136,137

Among the treatment groups, SAMe and B-vitamins co-supplementation, notably attenuated these histopathological features, as evidenced by preservation of pancreatic cellular architecture and morphology that closely approximated control tissues

however, IGF-I is important for normal growth to occur both pre- and postnatally

Ferroptosis inducer, sorafenib, is a multikinase inhibitor used as a drug to inhibit cancer cell proliferation and angiogenesis [86]

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Finally, coverslips were mounted using neutral balsam