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We also examined other ECM proteins, specifically LAMA5 and COL4A, and observed striking changes in their composition and formation of dense clusters specifically in GPX2 -deficient cells (Fig

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Combined therapy with L-arginine and L-norvaline further enhances these effects by reducing IL-17A expression, lowering peroxynitrite-induced oxidative stress, and inhibiting iNOS activity to restore arginine metabolic balance [86]

Agamennone M., Fantacuzzi M., Vivenzio G., Scala M

Barbuti AM, Chen ZS

When ferroptosis occurs, there is an increase in levels of a small range of divalent irons, which is referred to as unstable iron pool phenomenon (LIP) ( 3+ transferrin (TF) binds and is transported to tissues