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[DOI] [PMC free article] [PubMed] [Google Scholar] Setny P
In addition, the SOCS gene is activated by GH signaling and works as a short intracellular negative feedback loop which rapidly down-regulate GHR activity by internalization and receptor ubiquitinoylation resulting in lysosomal and proteasomal degradation (101)

however, it can mimic more serious conditions such as a heart attack or pulmonary embolism

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Vitamin B12 deficiency as a worldwide problem

Likewise, a positive cell-based assay or preclinical model result cannot be used as a substitute for validated clinical evidence
