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For example, leakage of electrons leading to superoxide anion (O2) generation may occur during the electron transport through the mitochondrial respiratory chain.1 Similarly, O2 may be generated during the microsomal, cytochrome-P450-mediated hydroxylation of endo and exogenous compounds for detoxification

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Despite being originally classified as a non-essential amino acid [32] in healthy individuals [33], abundant evidence suggests that glutamine is essential in specific stress situations such as severe illness, trauma, and overtraining [9, 34,35,36,37,38]

The main drawbacks of such methods are the difficulty of achieving cell type-specific profiling if suitable surface markers (that can be targeted by antibodies) are unavailable and, for future applications, the challenge of delivering large antibody reagents and high-intensity light into animals and tissue

Magesh S, Cai D

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