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For instance, inhibiting NNMT in white adipose tissue using small molecule inhibitors (like 5-Amino-1MQ analogs) increased energy expenditure and reduced weight gain in diet-induced obese mice, independent of food intake (Kraus D, 2014)

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note in Nature Medicine , NNMT inhibition has been shown to enhance energy expenditure and promote fat loss, even without dietary modification (Kraus et al., Nature Medicine )

Most evidence preclinical

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