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Food, beverages, and other medications can interfere with absorption by: Blocking contact between the medication and stomach lining Changing stomach acidity Moving the medication too quickly through the digestive system Reducing the amount of medication absorbed When absorption is reduced, the medication may be less effective at controlling appetite, improving blood sugar, and supporting weight loss

For example, some people are more prone to folate deficiency and may need to supplement if not eating enough folate-rich foods

However, the prescription must match the primary indication

Some patients find that they still consume enough calories to prevent a deficit, particularly if they are eating calorie-dense foods in smaller quantities (e.g

For now, compounded semaglutide remains available in many areas, though its long-term future is uncertain

This update was prepared for World Obesity Day 2026