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However, despite efficient absorption at the intestinal level, systemic bioavailability of free HTY is substantially limited due to rapid phase II metabolism in the intestinal epithelium and liver, leading to the formation of sulfate and glucuronide conjugates prior to entry into systemic circulation [38, 39]

3,4 The effect of UVR on DNA is accredited to the DNA nucleobases of irradiated cells absorbing photons in the UV region, resulting in several cytosolic effects, mutagenic DNA lesions and DNA strand breaks

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A genotyping study also revealed the presence of the wildtype VV/FF, double homozygous alleles (GG/CC), VG/CC and GG/FC derived from the F1534C and V1016G mutations in Yangon City [137]

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