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The effectiveness of GLME in the treatment of arthritis in cats and dogs The effectiveness of GLME in the treatment of arthritis is supported by studies demonstrating that GLME also reduces signs of joint disease in cats and dogs with degenerative joint disease (DJD) 10,12,25 , a condition similar in pathophysiology to human arthritis

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ENDOCRINE, NUTRITIONAL AND METABOLIC DISEASES E84 CYSTIC FIBROSIS 4th Includes: mucoviscidosis Code also exocrine pancreatic insufficiency (K86.81) E84.0 Cystic fibrosis with pulmonary manifestations Use additional code to identify any infectious organism present, such as: Pseudomonas (B96.5) E84.1 Cystic fibrosis with intestinal manifestations E84.11 Meconium ileus in cystic fibrosis 5th Excludes1: meconium ileus not due to cystic fibrosis (P76.0) E84.19 Cystic fibrosis with other intestinal manifestations Distal intestinal obstruction syndrome E84.8 Cystic fibrosis with other manifestations E84.9 Cystic fibrosis, unspecified E86 VOLUME DEPLETION 4th E87 OTHER DISORDERS OF FLUID, ELECTROLYTE AND ACIDBASE BALANCE 4th Excludes1: diabetes insipidus (E23.2) electrolyte imbalance associated with hyperemesis gravidarum (O21.1) electrolyte imbalance following ectopic or molar pregnancy (O08.5) familial periodic paralysis (G72.3) E87.0 Hyperosmolality and hypernatremia Refer to code P74.2 for transitory neonatal sodium imbalance Sodium [Na] excess Sodium [Na] overload E87.1 Hypo-osmolality and hyponatremia Sodium [Na] deficiency Excludes1: syndrome of inappropriate secretion of antidiuretic hormone (E22.2) E87.2 Acidosis Acidosis NOS Lactic acidosis Metabolic acidosis Respiratory acidosis Excludes1: diabetic acidosis see categories E08 E10, E13 with ketoacidosis E87.3 Alkalosis Alkalosis NOS Metabolic alkalosis Respiratory alkalosis E87.4 Mixed disorder of acid-base balance E87.5 Hyperkalemia Refer to code P74.3 for transitory neonatal potassium imbalance Potassium [K] excess Potassium [K] overload E87.6 Hypokalemia Potassium [K] deficiency E87.7 Fluid overload Excludes1: edema NOS (R60.9) 5th fluid retention (R60.9) E87.70 Fluid overload, unspecified E87.71 Transfusion associated circulatory overload Fluid overload due to transfusion (blood) (blood components) TACO E87.79 Other fluid overload E87.8 Other disorders of electrolyte and fluid balance, NEC Electrolyte imbalance NOS Hyperchloremia Hypochloremia 4th 5th 6th 7th Additional Character Required 3-character code PEDIATRIC ICD-10-CM 2019: A MANUAL FOR PROVIDER-BASED CODING ICD_10-4th_ed.indb 167 E88 OTHER AND UNSPECIFIED METABOLIC DISORDERS 4th Use additional codes for associated conditions E88.0 Disorders of plasma-protein metabolism, NEC Excludes1: disorder of lipoprotein metabolism (E78.-) 5th monoclonal gammopathy (of undetermined significance) (D47.2) polyclonal hypergammaglobulinemia (D89.0) Waldenstrm macroglobulinemia (C88.0) E88.01 Alpha-1-antitrypsin deficiency AAT deficiency E88.02 Plasminogen deficiency Dysplasminogenemia Hypoplasminogenemia Type 1 plasminogen deficiency Type 2 plasminogen deficiency Code also, if applicable, ligneous conjunctivitis (H10.51) Use additional code for associated findings, such as: hydrocephalus (G91.4) ligneous conjunctivitis (H10.51) otitis media (H67.-) respiratory disorder related to plasminogen deficiency (J99) E88.09 Other disorders of plasma-protein metabolism, NEC Bisalbuminemia E88.1 Lipodystrophy, NEC Lipodystrophy NOS E88.2 Lipomatosis, NEC Lipomatosis NOS Lipomatosis (Check) dolorosa [Dercum] E88.3 Tumor lysis syndrome Tumor lysis syndrome (spontaneous) Tumor lysis syndrome following antineoplastic drug chemotherapy Use additional code for adverse effect, if applicable, to identify drug (T45.1X5) E88.4 Mitochondrial metabolism disorders Excludes1: disorders of pyruvate metabolism (E74.4) 5th Kearns-Sayre syndrome (H49.81) Lebers disease (H47.22) Leighs encephalopathy (G31.82) Mitochondrial myopathy, NEC (G71.3) Reyes syndrome (G93.7) E88.40 Mitochondrial metabolism disorder, unspecified E88.41 MELAS syndrome Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes E88.42 MERRF syndrome Myoclonic epilepsy associated with ragged-red fibers Code also progressive myoclonic epilepsy (G40.3-) E88.49 Other mitochondrial metabolism disorders E88.8 Other specified metabolic disorders E88.81 Metabolic syndrome 5th Dysmetabolic syndrome X Use additional codes for associated manifestations, such as: obesity (E66.-) E88.89 Other specified metabolic disorders Launois-Bensaude adenolipomatosis Excludes1: adult pulmonary Langerhans cell histiocytosis (J84.82) CHAPTER 4

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