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Among these, mast cell histamine is an axial player in stimulating the development of allergic-related inflammatory diseases by regulating the maturation and activation of leukocytes and directing their migration to target sites where they cause chronic inflammation (58)

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The reactivity is enhanced when the thiol is ionized, and cysteine residues in proteins have pK a values close to neutrality, so are often in their reactive thiolate form in the cell
