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As a result, the rapid metabolism leads to an unexpected decrease in the drug concentration and, thereby, to a therapeutic failure [59]

By reducing the levels of these hydroperoxides, GPX4 inhibits the formation of more reactive and damaging lipid radicals, particularly protecting cells with membranes rich in PUFAs, which are highly susceptible to peroxidation (143,146)

Shukla, A., Srivastava, S., Mishra, V., Kumar, K

Barbosa A, Arajo D, Henriques M, Silva S

PLoS One 13 (5), e0197486

Anti-inflammatory effects The tumor microenvironment is similar to inflammatory lesions and plays a very important role in carcinogenesis