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Description
GH secretagogues have varying levels of human trial data depending on which one

Plasma folate, methylenetetrahydrofolate reductase (MTHFR), and colorectal cancer risk in three large nested case-control studies

Groups at higher risk of deficiency include older adults (due to reduced stomach acid production), people following vegan or strict vegetarian diets (as B12 is naturally found almost exclusively in animal products), individuals with pernicious anaemia or other malabsorption conditions, those taking certain medications such as metformin or proton pump inhibitors long-term, and people with significant nitrous oxide exposure (including recreational use), which can inactivate B12 in the body

Neurochem Res 22:727733 Kahan FM, Kropp H, Sundelof JG, Birnbaum J (1983) Thienamycin: development of imipenem-cilastatin
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B., Howitt J., Mccorkle S., Lawrence P., Springer K., Freimuth P
