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We are inviting public comment on whether TECVAYLI TM meets the newness criterion, including whether TECVAYLI TM is substantially similar to elranatamab and whether these technologies should be evaluated as a single technology for purposes of new technology add-on payments

In the past, antibodies meant to activate TREM2 failed in clinical trialsthey turned out to drive internalization of the receptor, effectively switching it off

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The following examples are offered to illustrate but not to limit the invention

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