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XOR appears to have a dichotomous role in tumor biology: XOR products are associated with both induced mutagenesis and cell proliferation, as well as with cell differentiation and apoptosis (399)

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10.1371/journal.pone.0235381 PLoS One

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Also, in patients with elevated NAD + (such as those suffering from metabolic syndrome 31 ), NAD + booster use needs careful consideration due to potential exacerbation of insulin resistance

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