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: Direct stimulation of 1 -Adrenergic Activation 1 -adrenergic receptors on myocytes increases myocardial chronotropy (heart rate) and inotropy (contractile force), thereby elevating or maintaining cardiac output (CO), depending on the dose used (Solanki et al, 2014)

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10.1146/ANNUREV-PHARMTOX-052220-103416 [DOI] [PubMed] [Google Scholar] Cuadrado A, Rojo AI, Wells G et al (2019) Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

A team of researchers recently conducted a small study that suggests some children can find relief from their autism symptoms by receiving methyl B12 injections, which improve their DNA methylation