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Both tests came back negative: AOD9604 did not cause mutations in bacteria and did not damage chromosomes in mammalian cells

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In line with this, global gene expression analysis and GSEA analyses revealed that expression of intracellular signal transducers involved in TNF-mediated activation of NFkB, MAPK and JNK (c-Jun N-terminal kinases) pathways such as Cd27 and Traf1 (TNF receptor associated factor 1), and other members of TNFR-signalling pathways such as Casp3 and Casp9 were significantly decreased in skeletal muscle of Cpt1b m/ mice compared to Cpt1b fl/fl mice (Table 1)
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[DOI] [PubMed] [Google Scholar] 5.Caputo T, Gilardi F, Desvergne B

Women who are pregnant, planning pregnancy, or breastfeeding should avoid the compound entirely due to unknown effects on fetal and infant development
