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Therefore, to enhance mitochondrial complex I activity, NAD + levels were boosted in fly models of PD with NAM, leading to reduced oxidative stress, including lower ROS levels and DNA damage, as well as improved climbing ability 281

doi: 10.1186/s11671-016-1517-3 219

doi:10.1161/CIRCULATIONAHA.105.580332 [15] Guenther BD, Sheppard CA, Tran P, Rozen R, Matthews RG, Ludwig ML

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