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The underlying mechanism is believed to be associated with estrogens influence on critical brainstem regions integral to neurocardiovascular regulation (54)

Thus, higher organisms use coordinated organ systems and specialized proteins to regulate the uptake, distribution, and excretion of Mn to maintain systemic homeostasis and balance these dual roles in health and disease 5

[DOI] [PubMed] [Google Scholar] 130.Sadeghi O., Milajerdi A., Siadat S.D., Keshavarz S.A., Sima A.R., Vahedi H., Adibi P., Esmaillzadeh A

They also serve as key regulatory factors in inflammation of the female reproductive tract, malignant tumors, and pregnancy (Ghartey et al., 2015

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A stable structure that binding to HER2 proteins inhibits HER2 degradation, leading to sustained activation of the PI3K-AKT and RAS-MAPK signaling pathways, which contribute to BRCA progression 33