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The functional mechanisms linking specific microbial taxa or microbial-derived metabolites to endocrine and metabolic disturbances also remain incompletely understood
These natural levels may be depleted over time by stress, aging, and poor lifestyle choices, and can lead to more free radicals in the body
The HFI series of compounds, e.g., 37 (HFI 419) identified in 2008 after the virtual screening are much more drug-like than the hexapeptides 11 (AL-11), 12 (IVDE77), and the potent macrocyclic Ang IV analogue 23 (HA08) and can hopefully after further systematic optimization be converted into bioactive small molecules with capacity to cross the blood-brain barrier
Tamura et al., 2010)
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