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10 WADA Prohibited ListClassification of SLU-PP-332 as a prohibited substance (S4.5 metabolic modulators) in competitive sport

In case of low bile acid absorption, FXR is not activated, FGF19 stays low and bile acid synthesis is stimulated

Further hydroxylation of tyrosine, combined with its decarboxylation leads to the catecholamine neurotransmitter dopamine , which in can be further derivatized to norepinephrine and epinephrine

Are we getting closer to the point where the real bottleneck is not innovation itself, but the lack of predictive enough models to back the right programs earlier and stop the wrong ones sooner

Sikirzhytski, V., et al

Halbeisen et al., 2018)
