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Indeed, such abnormal presence of mitochondria in circulating red blood cells causes increased oxygen consumption, ROS generation, and hemolysis in SCD patients 50,51

Etavopivat Etavopivat (FT-4202) is another small-molecule PK activator in clinical development for SCD and thalassemia

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(2017) 114:E8711e20

5 The relationship between EMS-induced GCs abnormalities and oocyte quality Current research indicates that EMS-induced oxidative stress, inflammation, aberrant mitochondrial energy metabolism, inappropriate steroid production, and apoptosis in GCs can all impair the quality of oocytes to variable degrees

Discussion In this study, we found that the patients with high SOD or GR may have a more favorable prognosis than those with low SOD or GR