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25 In the early 1990s, despite John Engs team identifying a potential diabetes treatment in exendin-4, it initially lacked attention and funding for development
It highlights the ability of peripheral liraglutide to cross the BBB and specifically target hypothalamic ARC cells, eliciting significant appetite suppression and subsequent weight loss
The most common issues are nausea, vomiting, diarrhea, and stomach pain
Can I switch from semaglutide to tirzepatide
Third, the kidney-protective effects of GLP-1s, particularly semaglutide, are relevant for lupus nephritis patients who are already at elevated risk for progressive kidney disease
