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32,44,45 While SIRT6 is widely recognized as a tumor suppressor and lipid reducer in certain contextssuch as in the liver, where it suppresses lipogenic pathways 46 or promotes fatty acid -oxidation, 32 and in cardiomyocytes, where it inhibits PPAR-mediated fatty acid uptake 47 emerging evidence underscores its functional diversity

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As such, HDL are in a constant state of remodeling and interconversion

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