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thus a deficiency may lead to disruption of DNA synthesis/cell metabolism and have serious clinical consequences

Sterile water would require either using all 10mg immediately or risking every subsequent dose

There was an overall weight gain in these patients and a decrease in the frequency of clinical signs such as vomiting and diarrhea

Hydroxocobalamine (Sigma-Aldrich, Germany), Ethylenediaminetetraacetic acid (EDTA), propylene glycol (PG), polyethylenglycole (PEG 400), sorbitan mono oleate and buffering agents (Citrate, Acetate and Phosphate) were provided by Merck- Schuchardt, Hohenbrunn, Germany