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Effect of surface charge on the brain delivery of nanostructured lipid carriers in situ gels via the nasal route

Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression
Walnut Diet Reduces Accumulation of Polyubiquitinated Proteins and Inflammation in the Brain of Aged Rats. Journal of Nutritional Biochemistry 24, no
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It can also play a role in many immune-mediated diseases such as allergies, inflammatory bowel disease, otitis, pancreatitis, cancer and asthma

Since many pathologic and toxic conditions result in sustained increase in cytosolic free Ca 2+ , which can lead to activation of CMK and phosphorylation of GCLC, theoretically, inhibition of GCL may further contribute to toxicity under these conditions
