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Together, these results suggest that leptin-mediated LepR dimerization is primarily driven by the aromatic and polar contacts formed by leptin residues Tyr119 and S120 at site 3a, with the receptor-induced conformational change of the leptin AB loop playing a secondary role to further stabilize the LepR dimer and enable maximal STAT3 activation

10.1016/J.NEUROPHARM.2017.06.015 136 WoodwardM

Combining the targeted and untargeted screening of environmental contaminants reveals associations between PFAS exposure and vitamin D metabolism in human plasma

[DOI] [PMC free article] [PubMed] [Google Scholar] [2].Kumar A, Narayan RK, Prasoon P, Kumari C, Kaur G, Kumar S, et al

Stomach acid tends to decrease with age, which makes it harder to extract B12 from food