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This depletion correlates directly with elevated ventricular lactate levels, providing concrete biological evidence that the brains of these patients are trapped in a state of high oxidative stress and inefficient anaerobic metabolism

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On the basis of this association, Fine et al 88 proposed in 2000 that chronic hypoxia is the final common pathway that leads to the development of end-stage renal failure

Clients who receive B12 shots for energy report feeling noticeably more alert, focused, and activeoften within 24-48 hours

Lancet 398:21602172