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Among over 20 distinct RCD modalities reported, ferroptosis, described as a ROS-dependent non-apoptotic iron-driven cell death [496], has attracted considerable attention as a potential therapeutic target in cancer [497]

PMID: 41111053 Nat Neurosci GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy

Regardless of skin tone, the human epidermis contains a remarkably stable melanin composition of roughly 74% eumelanin and 26% pheomelanin

Supporting this cofactor-binding mode, mutations of residues that interact with NADP have been shown by previous enzymological studies to either decrease or abolish the catalytic activity of SRD5A2 (Extended Data Fig