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This drug was shown to induce senescence both in vitro and in vivo in HCT116 models [80]

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As we age, the superficial blood vessels in the skin become visible through the skin, giving a darker appearance

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Analysis was conducted using an LC-MS QTRAP 6500+ system (SCIEX) equipped with a BEH C18 column (2.1 mm 10 cm, 1.7 m, Waters) and operated in ESI+ or ESI mode

Diagnostic dilemmas could occur when patients with PA present with spuriously normal or high cobalamin levels, normocytic or microcytic anaemia, nonanaemic macrocytosis, autoimmune haemolytic anaemia, pseudo-thrombotic microangiopathy, hyperhomocysteinemia-associated thromboembolism, pseudoleukemia, bone marrow failure, and neurologic manifestations without anaemia or macrocytosis