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So statements that topical AHK-Cu is "well tolerated" rest on the copper-peptide class generally much of it built on GHK-Cu (Pickart & Margolina 2018, PMID 29986520) and on community use, rather than on dedicated AHK-Cu safety study

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Current non-surgical curative regenerative therapies for knee osteoarthritis. Stem cell reviews and reports 20.8 (2024): 2104-2123