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According to the National Institutes of Health, even at high levels, B12 isnt toxic and is generally considered safe because your body doesnt store excess amounts

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The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18

13,14,15,16,17,18 Currently, the disease can only be diagnosed by DNA sequencing, and only a subset of individuals have detectable reductions in Asn levels in serum and cerebrospinal fluid, hindering the use of this test for initial screening

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360 Novel agents such as LW-216 (Sec498-targeted TRXR1 degradation), 361 6-shogaol (selenocysteine inhibition), 362 and Nitrovin induce caspase-3-independent paraptosis via MAPK/Alix modulation