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Researchers speculate that stress and environmental stimuli trigger cascades involving mast cells and microglia, leading to abnormal synaptic pruning and dysfunctional neuronal connectivity [528] in brain pathology

MOTS-c directly connects the mitochondria to exercise-induced signaling

10.1093/nar/gkt1012 Nucleic Acids Res

Furthermore, B cells contribute to maintaining local tolerance by promoting the differentiation of Tregs and by scavenging apoptotic debris in the glomeruli to prevent the formation of autoantibodies
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J., Weiss, J
